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Association details:
Biomarker:CDK7 overexpression
Cancer:Uveal Melanoma
Drug:SNS-032 (CDK inhibitor)
Direction:Sensitive
Evidence:
Evidence Level:
Sensitive: D – Preclinical
Source:
Title:

Transcriptional inhibition by CDK7/9 inhibitor SNS-032 abrogates oncogene addiction and reduces liver metastasis in uveal melanoma

Published date:
09/16/2019
Excerpt:
The results showed that CDK7/9 were highly expressed in UM cells, and SNS-032 significantly suppressed the cellular proliferation, induced apoptosis, and inhibited the outgrowth of xenografted UM cells and PDX tumors in NOD-SCID mice…
DOI:
https://doi.org/10.1186/s12943-019-1070-7