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Association details:
| Biomarker: | CDK7 overexpression |
|---|---|
| Cancer: | Uveal Melanoma |
| Drug: | SNS-032 (CDK inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Transcriptional inhibition by CDK7/9 inhibitor SNS-032 abrogates oncogene addiction and reduces liver metastasis in uveal melanoma
Published date:
09/16/2019
Excerpt:
The results showed that CDK7/9 were highly expressed in UM cells, and SNS-032 significantly suppressed the cellular proliferation, induced apoptosis, and inhibited the outgrowth of xenografted UM cells and PDX tumors in NOD-SCID mice…
DOI:
https://doi.org/10.1186/s12943-019-1070-7
