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    Association details:
    Biomarker:CDK14 overexpression
    Cancer:Esophageal Squamous Cell Carcinoma
    Drug:cisplatin (DNA synthesis inhibitor)
    Direction:Resistant
    Evidence:
    Evidence Level:
    Resistant: D – Preclinical
    New
    Source:
    Ann Transl Med
    Title:

    CDK14 involvement in proliferation migration and invasion of esophageal cancer

    Excerpt:
    Overexpression of CDK14 in Eca109 cells increased colony formation and reduced sensitivity to cisplatin. Expression of CDK14 worsened the effects of cisplatin chemotherapy by promoting ESCC proliferation.
    DOI:
    10.21037/atm.2019.11.105