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Association details:
| Biomarker: | CDH6 expression |
|---|---|
| Cancer: | Renal Cell Carcinoma |
| Drug: | CUSP06 (Topoisomerase I inhibitor, CDH6-targeted antibody-drug conjugate) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Abstract 6320: CUSP06/AMT-707, a new CDH6-targeting antibody-drug conjugate, demonstrates potent antitumor activity in preclinical models
Published date:
04/04/2023
Excerpt:
CUSP06 exhibited strong antiproliferative activity against several CDH6 positive cancer cell lines in vitro....Treatment with CUSP06 resulted in tumor regression in several CDH6 positive cell line derived xenograft (CDX) models, including PA-1, OVCAR3, and 786-O….The preclinical activity of CUSP06 against CDH6-expressing tumors provide compelling support for the clinical development of CUSP06 in CDH6-expressing human cancers.
DOI:
https://doi.org/10.1158/1538-7445.AM2023-6320
