^
Association details:
| Biomarker: | CDH1 expression |
|---|---|
| Cancer: | Non Small Cell Lung Cancer |
| Drug: | volasertib (NBL-001) (PLK1 inhibitor) |
| Direction: | Resistant |
Evidence:
Source:
Title:
Epithelial-Mesenchymal Transition Predicts Polo-Like Kinase 1 Inhibitor-Mediated Apoptosis in Non-Small Cell Lung Cancer
Excerpt:
Likewise, proteomic profiling demonstrated that E-cadherin expression was higher in the resistant cell lines than in the sensitive ones (P< 0.01)….In agreement with the finding that epithelial NSCLC cell lines were more resistant than mesenchymal cells to PLK1 inhibition, induction of an epithelial phenotype increased the cell lines’ resistance to treatment with volasertib...
DOI:
10.1158/1078-0432.CCR-14-2890
