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Association details:
| Biomarker: | CDH1 expression |
|---|---|
| Cancer: | Colon Cancer |
| Drug: | Hakin-1 (E3 ubiquitin-ligase hakai inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Novel small-molecule inhibitors of the E3 ubiquitin-ligase Hakai
Published date:
05/28/2021
Excerpt:
...in vitro analyses were performed to determine the antitumor activity of novel Hakin-1 analogues by analyzing E-cadherin levels at cell-cell contacts...E-cadherin results showed that at least two new compounds significantly increased E-cadherin expression at the cell junctions to the DMSO vehicle control, improving Hakin-1 efficacy.
