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Association details:
| Biomarker: | CDC42 elevation |
|---|---|
| Cancer: | Colorectal Cancer |
| Drug Class: | PD1 inhibitor |
| Direction: | Resistant |
Evidence:
Source:
Title:
Vertical level of blood cell division cycle 42 predicts response and survival benefits to PD-1 inhibitor-based regimen in metastatic colorectal cancer patients
Published date:
02/22/2023
Excerpt:
Fifty-seven inoperable mCRC patients who received PD-1 inhibitor-based regimens were recruited….Higher CDC42 at baseline (p = 0.016) and after 2-cycle treatment (p = 0.002) were both linked with decreased objective response rate. CDC42 high at baseline was related to shorter progression-free survival (PFS) (p = 0.015) and overall survival (OS) (p = 0.050).
DOI:
https://doi.org/10.1080/00365513.2023.2175330