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    Association details:
    Biomarker:CD8 overexpression
    Cancer:Non Small Cell Lung Cancer
    Drug:sasanlimab (PF-06801591) (PD1 inhibitor)
    Direction:Sensitive
    Evidence:
    Evidence Level:
    Sensitive: C3 – Early Trials
    Source:
    AACR-I 2020
    Title:

    Abstract CT138: Molecular markers in a phase I dose expansion study of PF-06801591 in locally advanced or metastatic non-small-cell lung cancer and urothelial carcinoma

    Published date:
    04/27/2020
    Excerpt:
    In NSCLC, high baseline CD8 protein expression in certain tumor compartments was associated with better objective response rate (ORR), PFS and OS. High TMB was associated with prior smoking status and better ORR.
    DOI:
    10.1158/1538-7445.AM2020-CT138