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    Association details:
    Biomarker:CD8 elevation + BRAF V600
    Cancer:Melanoma
    Drug:dacarbazine (DNA synthesis inhibitor)
    Direction:Sensitive
    Evidence:
    Evidence Level:
    Sensitive: C3 – Early Trials
    Source:
    Curr Probl Cancer
    Title:

    Theragnostic significance of tumor-infiltrating lymphocytes and Ki67 in BRAFV600-mutant metastatic melanoma (BRIM-3 trial)

    Published date:
    04/02/2022
    Excerpt:
    High intratumoral and high peritumoral CD8 TIL score was significantly associated with progression-free survival (PFS) only in DTIC-treated patients (P = 0.002 and 0.037, respectively)....High peritumoral CD8 TIL score is a favorable prognostic factor independent of well-established AJCC staging factors.
    DOI:
    10.1016/j.currproblcancer.2022.100862