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Association details:
| Biomarker: | CD74-ROS1 G2032R |
|---|---|
| Cancer: | Non Small Cell Lung Cancer |
| Drug: | Xalkori (crizotinib) (ALK inhibitor) |
| Direction: | Resistant |
Evidence:
Source:
Title:
Molecular Changes Associated with Acquired Resistance to Crizotinib in ROS1-Rearranged Non–Small Cell Lung Cancer
Excerpt:
Here, we identified molecular alterations in crizotinib-resistant tumors from two NSCLC patients with the CD74–ROS1 rearrangement….Ba/F3 cells expressing ROS1-mutant CD74–ROS1 transcripts showed resistance to crizotinib.
DOI:
10.1158/1078-0432.CCR-14-1350
Trial ID:
