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Association details:
Evidence:
Evidence Level:
Sensitive: C4 – Case Studies
Title:

Acquired MET D1228N Mutations Mediate Crizotinib Resistance in Lung Adenocarcinoma with ROS1 Fusion: A Case Report

Published date:
09/30/2020
Excerpt:
...patient with metastatic lung adenocarcinoma with CD74‐ROS1 fusion who initially responded to crizotinib and then developed resistance by the acquired mutation of D1228N in the MET kinase domain, which showed short‐term disease control for cabozantinib...experienced significant improvement with her headaches within 2 weeks, although her appetite was affected. After 1 month, an imaging assessment revealed shrinkage of both brain metastases and lung lesions...
DOI:
10.1002/onco.13545