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Association details:
| Biomarker: | CD74 expression |
|---|---|
| Cancer: | Acute Lymphocytic Leukemia |
| Drug: | STRO-001 (Microtubule inhibitor, CD74-targeted antibody-drug conjugate) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Therapeutic Targeting of CD74 with STRO-001 Antibody-Drug Conjugate in AML and ALL
Published date:
11/04/2021
Excerpt:
We evaluated the in vitro cytotoxicity of STRO-001...AML cell lines (MV4;11 and NOMO-1), and ALL cell lines (REH1 and RS4;11) with varied CD74 expression. STRO-001 demonstrates target-specific cytotoxicity against CD74-expressing AML and ALL cell lines...STRO-001 exhibited high potency in CD74 expressing cells, with IC-50s of 41nM (MV4;11), 1.3nM (NOMO-1), 0.7nM (REH-1) and 3nM (RS4;11).
DOI:
10.1182/blood-2021-151160
