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Association details:
| Biomarker: | CD73 overexpression |
|---|---|
| Cancer: | Gastric Cancer |
| Drug: | Keytruda (pembrolizumab) (PD1 inhibitor) |
| Direction: | Resistant |
Evidence:
Source:
Title:
Impact of intratumoural CD73 expression on prognosis and therapeutic response in patients with gastric cancer
Published date:
11/01/2021
Excerpt:
CD73 high tumours indicated better chemotherapeutic responsiveness to fluorouracil yet a worse objective response rate to pembrolizumab in GC….High CD73 expression indicated an immunoevasive contexture with CD8+ T cell dysfunction and represented an independent predictor for adverse clinical outcomes.
DOI:
10.1016/j.ejca.2021.08.006
