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Association details:
| Biomarker: | CD70 expression |
|---|---|
| Cancer: | Renal Cell Carcinoma |
| Drug: | ALLO-316 (CD70-targeted CAR-T immunotherapy) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
392 Engineering CD70-directed CAR-NK cells for the treatment of hematological and solid malignancies
Published date:
11/08/2022
Excerpt:
In functional assays, CD70 knockout CAR-NK cells mediated cytotoxicity against multiple CD70-positive tumor cell lines including AML and RCC both in vitro and in vivo….Overall, the results demonstrate the potential for targeting CD70 with CAR-NK cell therapy for the treatment of AML, RCC, and other CD70-positive malignancies...
DOI:
http://dx.doi.org/10.1136/jitc-2022-SITC2022.0392
