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Association details:
| Biomarker: | CD70 expression |
|---|---|
| Cancer: | B Acute Lymphoblastic Leukemia |
| Drug Class: | CD70-targeted CAR-T immunotherapy |
| Direction: | Sensitive |
Evidence:
Source:
Title:
ANTI-LEUKEMIA ACTIVITY OF CD70-DIRECTED IMMUNOTHERAPY IN B CELL PRECURSOR ACUTE LYMPHOBLASTIC LEUKEMIA
Published date:
05/11/2023
Excerpt:
We studied CD70 expression profiles in different cohorts of BCP-ALL samples and evaluated CD70 as immunotherapeutic target using CD70-directed antibodies in vitro, ex vivo and in vivo...Therefore, we further evaluated CD70 as target for directed immunotherapy. Anti-CD70 monoclonal antibodies displayed antibody dependent cell mediated cytotoxicity against primary BCP-ALL cells and cell lines with CD70 expression in vitro....Moreover, we also investigated anti-CD70 activity in a pre-clinical model of manifest ALL and observed a dose-dependent, significant leukemia reduction in treated animals.
