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    Association details:
    Biomarker:CD44 overexpression + CD24 underexpression
    Cancer:Esophageal Squamous Cell Carcinoma
    Drug:cisplatin (DNA synthesis inhibitor) +
    5-fluorouracil (Thymidylate synthase inhibitor)
    Direction:Resistant
    Evidence:
    Evidence Level:
    Resistant: C3 – Early Trials
    Source:
    Anticancer Res
    Title:

    Simple Cancer Stem Cell Markers Predict Neoadjuvant Chemotherapy Resistance of Esophageal Squamous Cell Carcinoma

    Published date:
    07/19/2021
    Excerpt:
    We included 171 patients with ESCC who underwent the FP-NAC....The biopsy specimens of the non-responders had the CD44 high/CD24low expression at high levels, which was found as an independent predictor of not only FP-NAC resistance but also poor overall survival by multivariate analyses.
    DOI:
    https://doi.org/10.21873/anticanres.15214