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Association details:
| Biomarker: | CD40L negative |
|---|---|
| Cancer: | Non-Hodgkin’s Lymphoma |
| Drug: | luxeptinib (CG-806) (BTK inhibitor, FLT3 inhibitor, Myeloid kinome inhibitor, Lymphoid kinome inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
1174 Pharmacologic Inhibition of B Cell-Receptor-Associated Kinases with CG-806 Induces Apoptosis and Metabolic Reprogramming in Aggressive Non-Hodgkin Lymphoma (NHL) Models
Published date:
11/04/2020
Excerpt:
Treatment with CG-806, but not ibrutinib, induced apoptosis of primary MCL cells in CD40L- or BAFF-expressing stromal co-cultures...These results provide rationale for further investigation of CG-806 in aggressive NHL.
