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Association details:
| Biomarker: | CD38 expression |
|---|---|
| Cancer: | Multiple Myeloma |
| Drug: | SAR442257 (CD3 agonist, CD38 inhibitor, CD28 agonist) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Abstract 5641: CD28 expression on multiple myeloma cells enhances the cytotoxic activity of CD38/CD28xCD3 trispecific T cell engager
Published date:
05/15/2020
Excerpt:
In vitro killing assays showed that SAR442257 is active on both CD38 high and CD38 low MM cell lines (EC50 in the pM range for WT cell lines; Table 1).
DOI:
10.1158/1538-7445.AM2020-5641
