^
Association details:
| Biomarker: | CD38 expression |
|---|---|
| Cancer: | Multiple Myeloma |
| Drug: | SAR442085 (CD38 inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Abstract 2266: SAR442085, a next generation anti-CD38 antibody with enhanced antibody-dependent cellular cytotoxicity (ADCC) against multiple myeloma
Published date:
05/15/2020
Excerpt:
...SAR442085 demonstrated potent in vivo single–agent activity against murine tumor cells expressing human CD38, in a transgenic C57BL/6 mouse model humanized for all Fcγ receptors, with 90% mice survival at 10 and 1.25 mg/kg and up to 90 days median survival time.
DOI:
10.1158/1538-7445.AM2020-2266
