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Association details:
| Biomarker: | CD28-L |
|---|---|
| Cancer: | Solid Tumor |
| Drug Class: | PD1 inhibitor |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Abstract 2846A: CD28 shedding is a novel immune-regulatory mechanism found in cancer patients which directly inhibits anti PD-1 effect
Published date:
06/22/2020
Excerpt:
Evaluation of plasma samples from patients undergoing anti-PD1 therapy demonstrated an association of clinical response with decreased plasma levels of soluble CD28.
DOI:
10.1158/1538-7445.AM2020-2846A
