^
Association details:
Biomarker:CD28-L
Cancer:Solid Tumor
Drug Class:PD1 inhibitor
Direction:Sensitive
Evidence:
Evidence Level:
Sensitive: C3 – Early Trials
Source:
Title:

Abstract 2846A: CD28 shedding is a novel immune-regulatory mechanism found in cancer patients which directly inhibits anti PD-1 effect

Published date:
06/22/2020
Excerpt:
Evaluation of plasma samples from patients undergoing anti-PD1 therapy demonstrated an association of clinical response with decreased plasma levels of soluble CD28.
DOI:
10.1158/1538-7445.AM2020-2846A