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Association details:
| Biomarker: | CD276 overexpression |
|---|---|
| Cancer: | Triple Negative Breast Cancer |
| Drug Class: | B7-H3-targeted antibody-drug conjugate |
| Direction: | Sensitive |
Evidence:
Source:
Title:
627. Preclinical Evaluation of B7-H3-Targeted CAR-T Cells against Triple Negative Breast Cancer
Published date:
04/27/2021
Excerpt:
B7-H3-targeted CAR-T cells showed significant in vivo anti-tumor activity in orthotopic xenograft...B7-H3 is overexpressed in several TNBC cell lines and B7-H3-targeted CAR-T cells preferentially attack tumor cells with high B7-H3 expression.
