^
Association details:
Evidence:
Evidence Level:
Sensitive: D – Preclinical
Title:

MEK Inhibitor Augments Antitumor Activity of B7-H3-Redirected Bispecific Antibody

Published date:
08/25/2020
Excerpt:
B7-H3 × CD3 BiAb specifically and efficiently redirected their cytotoxicity against B7-H3 overexpressing tumor cells both in vitro and in xenograft mouse models. While trametinib treatment alone affected tumor growth, the combined therapy increased T cell infiltration and significantly suppressed tumor growth.
DOI:
10.3389/fonc.2020.01527