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    Association details:
    Biomarker:CD276 overexpression
    Cancer:Non Small Cell Lung Cancer
    Drug:Mekinist (trametinib) (MEK inhibitor)
    Direction:Sensitive
    Evidence:
    Evidence Level:
    Sensitive: D – Preclinical
    Source:
    Front Oncol
    Title:

    MEK Inhibitor Augments Antitumor Activity of B7-H3-Redirected Bispecific Antibody

    Published date:
    08/25/2020
    Excerpt:
    B7-H3 × CD3 BiAb specifically and efficiently redirected their cytotoxicity against B7-H3 overexpressing tumor cells both in vitro and in xenograft mouse models. While trametinib treatment alone affected tumor growth, the combined therapy increased T cell infiltration and significantly suppressed tumor growth.
    DOI:
    10.3389/fonc.2020.01527