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Association details:
| Biomarker: | CD276 overexpression |
|---|---|
| Cancer: | Breast Cancer |
| Drug: | ITC-6102RO (DNA replication inhibitor, B7-H3-targeted antibody-drug conjugate) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
ITC-6102RO, a novel B7-H3 antibody-drug conjugate, exhibits potent therapeutic effects against B7-H3 expressing solid tumors
Published date:
08/18/2023
Excerpt:
We assessed the cytotoxicity and internalization of ITC-6102RO in B7-H3 overexpressing cell lines in vitro and evaluated its anticancer efficacy and mode of action in B7-H3 overexpressing cell-derived and patient-derived xenograft models in vivo….ITC-6102RO inhibited cell viability in B7-H3-positive lung and breast cancer cell lines...
DOI:
https://doi.org/10.1186/s12935-023-02991-x
