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Association details:
| Biomarker: | CD276 expression |
|---|---|
| Cancer: | Pancreatic Ductal Adenocarcinoma |
| Drug Class: | B7-H3-targeted antibody-drug conjugate |
| Direction: | Sensitive |
Evidence:
Source:
Title:
1498 - Nanobody-based CAR T cells targeting B7-H3 in pancreatic cancer
Published date:
03/10/2021
Excerpt:
Notably, three nanobody-based CAR T cells (B12, C4 and G8) demonstrate potent cytolytic effects on B7-H3 positive PDAC and NB cell lines in vitro. In particular, CAR T cells have been tested in a metastatic PDAC model and a NB model in mice, showing that C4 and B12 nanobody-based CAR T cells have potent antitumor efficacy without evident side effects.
