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Association details:
| Biomarker: | CD276 expression |
|---|---|
| Cancer: | Breast Cancer |
| Drug: | vobramitamab duocarmazine (MGC018) (DNA replication inhibitor, B7-H3-targeted antibody-drug conjugate) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Preclinical Development of MGC018, a Duocarmycin-based Antibody-drug Conjugate Targeting B7-H3 for Solid Cancer
Published date:
09/23/2020
Excerpt:
...antitumor activity was observed toward patient-derived xenograft models of breast, prostate and head and neck cancer displaying heterogeneous expression of B7-H3.
DOI:
10.1158/1535-7163.MCT-20-0116
