^
Association details:
| Biomarker: | CD276 expression |
|---|---|
| Cancer: | Acute Myelogenous Leukemia |
| Drug: | SCRI-CARB7H3(s) (B7-H3-targeted CAR-T immunotherapy) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Preclinical Evaluation of B7-H3-Specific Chimeric Antigen Receptor T cells for the Treatment of Acute Myeloid Leukemia
Published date:
02/02/2021
Excerpt:
B7-H3 is expressed on monocytic AML cell lines and on primary AML blasts from patients with monocytic AML...B7-H3.CAR-Ts exhibit efficient antigen-dependent cytotoxicity in vitro and in xenograft models of AML, and are unlikely to cause unacceptable hematopoietic toxicity.
DOI:
10.1158/1078-0432.CCR-20-2540
