^
Association details:
| Biomarker: | CD27 overexpression |
|---|---|
| Cancer: | Clear Cell Renal Cell Carcinoma |
| Drug Class: | PD1 inhibitor |
| Direction: | Resistant |
Evidence:
Source:
Title:
Plasma CD27, a surrogate of the intratumoral CD27-CD70 interaction, correlates with immunotherapy resistance in renal cell carcinoma
Published date:
09/06/2022
Excerpt:
Tumor tissue from 25 ccRCC patients was assessed for the expression of CD27 and CD70 in situ using multiplex immunofluorescence....High sCD27 levels predicted poor overall survival in patients with RCC patients treated with anti-PD-1 in both the training and validation cohorts but not in patients treated with anti-angiogenic therapy.
DOI:
10.1158/1078-0432.CCR-22-0905
