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Association details:
| Biomarker: | CD19 positive |
|---|---|
| Cancer: | B Acute Lymphoblastic Leukemia |
| Drug: | SGN-CD19B (DNA replication inhibitor, CD19-targeted antibody-drug conjugate) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Therapeutic potential of SGN-CD19B, a PBD-based anti-CD19 drug conjugate, for treatment of B-cell malignancies
Excerpt:
The in vitro cytotoxicity of SGN-CD19B was evaluated across a broad panel of B-NHL and B-ALL cell lines….Results show SGN-CD19B is widely active against CD19+ tumor cell lines, with the majority of cell lines displaying robust sensitivity at or below 1 ng/mL.
DOI:
https://doi.org/10.1182/blood-2017-04-779389
