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Association details:
Evidence:
Evidence Level:
Sensitive: D – Preclinical
Source:
Title:

Transcriptional CDK inhibitors, CYC065 and THZ1 promote Bim-dependent apoptosis in primary and recurrent GBM through cell cycle arrest and Mcl-1 downregulation

Published date:
05/28/2021
Excerpt:
CYC065 and THZ1 induced apoptosis in isolated CD133 and CD44 biomarker-positive cells….CYC065 and THZ1 display high anti-tumour activity in primary and recurrent GBM...