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    Association details:
    Biomarker:CD133 positive
    Cancer:Glioblastoma
    Drug:fadraciclib (CYC065) (CDK9 inhibitor, CDK2 inhibitor) +
    SY‑079 (CDK7 inhibitor)
    Direction:Sensitive
    Evidence:
    Evidence Level:
    Sensitive: D – Preclinical
    Source:
    EACR 2021
    Title:

    Transcriptional CDK inhibitors, CYC065 and THZ1 promote Bim-dependent apoptosis in primary and recurrent GBM through cell cycle arrest and Mcl-1 downregulation

    Published date:
    05/28/2021
    Excerpt:
    CYC065 and THZ1 induced apoptosis in isolated CD133 and CD44 biomarker-positive cells….CYC065 and THZ1 display high anti-tumour activity in primary and recurrent GBM...