^
Association details:
| Biomarker: | CD133 positive |
|---|---|
| Cancer: | Glioblastoma |
| Drug: | CD133-specific CAR-T cell therapy (CD133-targeted CAR-T immunotherapy) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
The Rational Development of CD133-Targeting Immunotherapies for Glioblastoma
Published date:
05/27/2020
Excerpt:
CART133 cells demonstrated superior efficacy in patient-derived GBM xenograft models without causing adverse effects on normal CD133+ hematopoietic stem cells...Thus, CART133 cells may be a therapeutically tractable strategy to target CD133+ CSCs in human GBM or other treatment-resistant primary cancers.
DOI:
10.1016/j.stem.2020.04.008
