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    Association details:
    Biomarker:CCR8 expression
    Cancer:Solid Tumor
    Drug:FPA157 (CCR8 inhibitor)
    Direction:Sensitive
    Evidence:
    Evidence Level:
    Sensitive: D – Preclinical
    Source:
    Businesswire
    Title:

    Five Prime Presents First Preclinical Data on Anti-CCR8 Antibody FPA157

    Published date:
    11/10/2020
    Excerpt:
    CCR8 expression is highly restricted to T regulatory (Treg) cells within the tumor...FPA157 leads to potent natural killer (NK) cell-dependent killing of CCR8+ target cells...Preclinical data for FPA157 suggest that selective depletion of regulatory T cells within the tumor— without affecting peripheral Tregs...