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Association details:
| Biomarker: | CCR5 expression |
|---|---|
| Cancer: | Colorectal Cancer |
| Drug: | Avastin (bevacizumab) (VEGF-A inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
454P - CCR5/CCL5 gene expression in colorectal cancer (CRC): Comprehensive profiling and clinical value
Published date:
09/13/2021
Excerpt:
7604 CRC tested at Caris Life Sciences (Phoenix, AZ) with NextGen Sequencing on DNA and RNA were analyzed....CCR5 expression was associated with benefit from bevacizumab-based treatment in right-sided pMMR CRC (HR 0.39; 95%CI, 0.16-0.90, P = .024).
