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Association details:
| Biomarker: | CCNE1 overexpression |
|---|---|
| Cancer: | Ovarian Cancer |
| Drug: | SNS-032 (CDK inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Cyclin-dependent kinase 2 is an ideal target for ovary tumors with elevated cyclin E1 expression
Excerpt:
Ovarian cancer cells with elevated CCNE1 expression were 40 times more sensitive to Cdk2 inhibitorSNS-032 than those without inherent CCNE1 overexpression. Moreover, SNS-032 greatly prolonged the survival of mice bearing ovary tumors with inherent CCNE1 overexpression.
DOI:
10.18632/oncotarget.4600
