^
Association details:
| Biomarker: | CCNE1 amplification |
|---|---|
| Cancer: | Ovarian Cancer |
| Drug: | SNS-032 (CDK inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Cyclin E1 and RTK/RAS signaling drive CDK inhibitor resistance via activation of E2F and ETS
Excerpt:
OVCAR3, the only CCNE1-amplified cell line in this panel, displayed intermediate sensitivity for SNS032 and dinaciclib.
DOI:
10.18632/oncotarget.2673
