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Association details:
| Biomarker: | CCNE1 amplification |
|---|---|
| Cancer: | Ovarian Cancer |
| Drug: | APR-1051 (WEE1 inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
6177 / 6 - ATRN-119 and ATRN-W1051: Novel and potentially well tolerated ATR and WEE1 inhibitors for targeted cancer treatment
Published date:
03/15/2023
Excerpt:
Notably, daily oral dosing of ATRN-W1051 is well tolerated in mice and suppresses the growth of CCNE1-amplified HGSOC xenografted tumors. These preclinical data suggest that ATRN-W1051 may be a potential therapeutic candidate for CCNE1-overexpressing HGSOC.
