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Association details:
| Biomarker: | CCNE1 amplification |
|---|---|
| Cancer: | Gastric Cancer |
| Drug: | INX-315 (CDK2 inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
5994 / 23 - INX-315, a potent and selective CDK2 inhibitor, demonstrates robust antitumor activity in CCNE1-amplified cancers
Published date:
03/15/2023
Excerpt:
In CCNE1-amplified human ovarian and gastric cancer cell lines, INX-315 potently inhibited Rb phosphorylation, induced a G1 cell cycle arrest, and inhibited proliferation….Lastly, in CCNE1-amplified xenograft models of ovarian and gastric carcinomas, INX-315 inhibited Rb-phosphorylation and induced tumor regression.
