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Association details:
| Biomarker: | CCND3 T283A |
|---|---|
| Cancer: | Acute Myelogenous Leukemia |
| Drug: | Turalio (pexidartinib) (c-KIT inhibitor, FLT3 inhibitor, AKT inhibitor, CSF-1R inhibitor, FMS kinase inhibitor) |
| Direction: | Resistant |
Evidence:
Source:
Title:
Recurrent Mutations in Cyclin D3 Confer Clinical Resistance to FLT3 Inhibitors in Acute Myeloid Leukemia
Published date:
06/08/2021
Excerpt:
...individual mutations in CCND3 (Q276*, S264R, and T283A) were identified in 2 of 21 non-responders (one patient had both Q276* and S264R)....Mutations in CCND3, a gene not commonly mutated in AML, are a novel cause of clinical primary resistance to FLT3 inhibitors in AML...
DOI:
10.1158/1078-0432.CCR-20-3458
