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Association details:
| Biomarker: | CCND3 deletion |
|---|---|
| Cancer: | T Acute Lymphoblastic Leukemia |
| Drug: | Ibrance (palbociclib) (CDK4 inhibitor, CDK6 inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Therapeutic Targeting of the Cyclin D3:CDK4/6 Complex in T Cell Leukemia
Excerpt:
...these studies demonstrated that cyclin D3:CDK4/6 inhibition was able to efficiently suppress T-ALL progression leading to disease regression in vivo….PD-0332991 could be efficient in the treatment of relapsed T-ALL…
DOI:
https://dx.doi.org/10.1016%2Fj.ccr.2012.09.016
