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    Association details:
    Biomarker:CCND1 overexpression
    Cancer:Squamous Cell Skin Cancer
    Drug:everolimus (mTOR inhibitor)
    Direction:Resistant
    Evidence:
    Evidence Level:
    Resistant: C3 – Early Trials
    Source:
    ASCO 2018
    Title:

    Identification of genes associated resistance of everolimus in cutaneous squamous cell carcinoma.

    Published date:
    05/16/2018
    Excerpt:
    Skin squamous cell carcinoma (SCC) (A431 and HSC-1)...Ingenuity pathway analysis showed, CCND1 gene overexpression is most closely related to mTOR inhibitor resistance.
    DOI:
    10.1200/JCO.2018.36.15_suppl.e24208