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Association details:
| Biomarker: | CCND1 overexpression |
|---|---|
| Cancer: | Breast Cancer |
| Drug: | trebananib (AMG 386) (Angiopoietin 1 inhibitor, Angiopoietin 2 inhibitor, TIE-2 antagonist) |
| Direction: | Resistant |
Evidence:
Source:
Title:
Identification of biomarkers associated with therapeutic resistance: Quantitative protein/phosphoprotein analysis of ~750 patients across 8 arms of the neoadjuvant I-SPY 2 TRIAL for high-risk early stage breast cancer
Published date:
11/17/2020
Excerpt:
...high Cyclin D1 predicted non-response in VC, control, and AMG386...High levels of Cyclin D1, but not other cell cycle proteins, predict non-response to chemo-/targeted-therapy across arms and subtypes,…
