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    Association details:
    Biomarker:CCND1 expression
    Cancer:Mantle Cell Lymphoma
    Drug:Ibrance (palbociclib) (CDK4 inhibitor, CDK6 inhibitor)
    Direction:Sensitive
    Evidence:
    Evidence Level:
    Sensitive: D – Preclinical
    New
    Source:
    Blood
    Title:

    Mantle cell lymphoma cells express predominantly cyclin D1a isoform and are highly sensitive to selective inhibition of CDK4 kinase activity

    Excerpt:
    examined the effect of PD0332991 on the proliferation of the MCL cell lines....Mino cells that displayed the expression of only cyclin D1a appeared to be more sensitive, with the major effect seen at 50 nM.
    DOI:
    10.1182/blood-2006-04-016634