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Association details:
| Biomarker: | CCL21 elevation |
|---|---|
| Cancer: | Lung Adenocarcinoma |
| Drug Class: | Immunotherapy |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Tobacco exposure primes the secretion of CCL21 positively associated with tertiary lymphoid structure and response to immunotherapy
Published date:
06/27/2023
Excerpt:
Patients with elevated serum levels of CCL21 benefited more from immunotherapy….Patients with a smoking history exhibited higher levels of TLS via the CCL21-dependent mechanism, serum CCL21 was identified as a reliable biomarker for predicting the efficacy of immunotherapy.
DOI:
10.1136/jitc-2023-006939