^
Association details:
| Biomarker: | CCL2 overexpression |
|---|---|
| Cancer: | Acute Myelogenous Leukemia |
| Drug: | Mekinist (trametinib) (MEK inhibitor) |
| Direction: | Resistant |
Evidence:
Source:
Title:
Abstract 5942: An integrated approach reveals novel extrinsic pathways and cytokine signatures associated with drug response in acute myeloid leukemia
Published date:
06/23/2020
Excerpt:
...Venetoclax resistance correlated with augmented levels of cytokines such as IL-1 and IP-10 and growth factors such as PDGF. Further, trametinib resistance in AML samples is correlated with the upregulation of CCL11, MCP1, and TGFα but a downregulation of CCL22 levels.
DOI:
10.1158/1538-7445.AM2020-5942
