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Association details:
Evidence:
Evidence Level:
Resistant: D – Preclinical
Source:
Title:

Abstract 5942: An integrated approach reveals novel extrinsic pathways and cytokine signatures associated with drug response in acute myeloid leukemia

Published date:
06/23/2020
Excerpt:
...Venetoclax resistance correlated with augmented levels of cytokines such as IL-1 and IP-10 and growth factors such as PDGF. Further, trametinib resistance in AML samples is correlated with the upregulation of CCL11, MCP1, and TGFα but a downregulation of CCL22 levels.
DOI:
10.1158/1538-7445.AM2020-5942