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Association details:
| Biomarker: | CCAT2 overexpression |
|---|---|
| Cancer: | Breast Cancer |
| Regimen: | CMF (5-fluorouracil + cyclophosphamide + ) |
| Direction: | Resistant |
Evidence:
Source:
Title:
Long noncoding RNA CCAT2 reduces chemosensitivity to 5-fluorouracil in breast cancer cells by activating the mTOR axis
Published date:
02/15/2022
Excerpt:
All patients underwent radical mastectomy with neoadjuvant chemotherapy after three courses of CMF (cyclophosphamide 600 mg/m2 d1, d8, methotrexate 0.4 mg/kg d1, fluorouracil [5‐Fu] 12 mg/kg d1‐d5, 21 days as a cycle)....High CCAT2 expression was detected in BC tissues and BC drug‐resistant cells after neoadjuvant chemotherapy, and a negative link was revealed between CCAT2 expression and efficacy of neoadjuvant chemotherapy.
DOI:
10.1111/jcmm.17041
