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Association details:
| Biomarker: | CAV1 overexpression |
|---|---|
| Cancer: | Pancreatic Cancer |
| Drug: | SSH20 (Topoisomerase I inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
A novel protein-drug conjugate, SSH20, demonstrates significant efficacy in caveolin-1-expressing tumors
Published date:
08/05/2021
Excerpt:
SSH20 treatment significantly reduced tumor growth rate in shCtrl (Cav-1 proficient) groups (Figures 5B and 5D, left panels)…results suggest that SSH20 likely has improved efficacy in high Cav-1-expressing tumors....Our results confirm that (1) SSH20 is effective in lung and pancreatic cancer in vitro and in vivo with high Cav-1 expression, and (2) SSH20 is more potent than irinotecan with no apparent difference in overall toxicity in mouse models.
DOI:
10.1016/j.omto.2021.07.013
