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Association details:
| Biomarker: | CASP8 overexpression |
|---|---|
| Cancer: | Thyroid Gland Anaplastic Carcinoma |
| Drug: | carboplatin (Tubulin polymerization promoter) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Carboplatin synergistically triggers the efficacy of photodynamic therapy via caspase 3-, 8-, and 12-dependent pathways in human anaplastic thyroid cancer cells
Excerpt:
...this present study, the combination of photodynamic therapy (PDT) and chemotherapy has been studied in anaplastic thyroid cancer. Human anaplastic thyroid cancer cells FRO were treated with a chemotherapy drug, carboplatin...The enhanced expression of different apoptotic pathway-related proteins like Bax, cytochrome c, caspase 3, caspase 8, caspase 12, etc. also confirmed the higher efficacy of combination treatment.
DOI:
10.1007/s10103-013-1452-9
