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    Association details:
    Biomarker:CASP3 overexpression
    Cancer:Hodgkin Lymphoma
    Regimen: (bleomycin + dacarbazine + doxorubicin hydrochloride + vinblastine)
    Direction:Sensitive
    Evidence:
    Evidence Level:
    Sensitive: C3 – Early Trials
    Source:
    EHA 2018
    Title:

    ACTIVATED CASPASE-3 EXPRESSION BY HODGKIN AND REED-STERNBERG CELLS (HRS) IS A POWERFUL PROGNOSTIC FACTOR IN CLASSICAL HODGKIN LYMPHOMA (CHL) TREATED WITH ABVD OR EQUIVALENT REGIMENS

    Published date:
    05/17/2018
    Excerpt:
    After a median follow-up of 17.5 years, the 20-year freedom from progression (FFP) was 90% vs 65% for aC3high vs aC3low patients (p<0.0001)….In a large study with extremely long follow-up, aC3high HRS cell expression was associated with superior FFP after ABVD or equivalent regimens.