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    Association details:
    Biomarker:CASP3 overexpression + BCL2 negative
    Cancer:Hodgkin Lymphoma
    Regimen: (bleomycin + dacarbazine + doxorubicin hydrochloride + vinblastine)
    Direction:Sensitive
    Evidence:
    Evidence Level:
    Sensitive: C3 – Early Trials
    Source:
    EHA 2018
    Title:

    ACTIVATED CASPASE-3 EXPRESSION BY HODGKIN AND REED-STERNBERG CELLS (HRS) IS A POWERFUL PROGNOSTIC FACTOR IN CLASSICAL HODGKIN LYMPHOMA (CHL) TREATED WITH ABVD OR EQUIVALENT REGIMENS

    Published date:
    05/17/2018
    Excerpt:
    Eligible patients had biopsy-proven cHL treated with ABVD or equivalent regimens….The 20-year FFP for patients whose tumors were aC3high/BCL2neg, either aC3low or BCL2pos, and aC3low/BCL2pos was 91% vs 84% vs 60% (p<0.0001).