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Association details:
Biomarker:
CAD-ALK fusion
Cancer:
Colorectal Cancer
Drug:
Rozlytrek (entrectinib)
(
ALK inhibitor
,
TrkB receptor inhibitor
,
TrkC kinase inhibitor
,
TrkA receptor inhibitor
,
ROS1 inhibitor
,
JAK2 inhibitor
,
TNK2 inhibitor
)
Direction:
Sensitive
Evidence:
Evidence Level:
Sensitive: C3 – Early Trials
New
Source:
Br J Cancer
Title:
Novel CAD-ALK gene rearrangement is drugable by entrectinib in colorectal cancer
Excerpt:
…treatment of this patient with the ALK inhibitor entrectinib resulted in a durable objective tumour response.
DOI:
10.1038/bjc.2015.401
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