^
Association details:
| Biomarker: | CA9 overexpression |
|---|---|
| Cancer: | Solid Tumor |
| Drug: | BCA356 (Carbonic anhydrase IX inhibitor, IL-12 modulator) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
A novel bispecific BCA356 targeting tumour antigen CAIX conjugated to an attenuated IL12 demonstrates pre-clinical efficacy with potential for limited systemic toxicity
Published date:
11/08/2022
Excerpt:
Finally, efficacy studies in PBMC-based humanized mice models and transgenic mice models confirm that BCA356 is efficacious and safe in CAIX-overexpressing tumour bearing mice…Through these in vitro and in vivo studies, we demonstrate that BCA356 by its CAIX-targeted IL-12v delivery approach is both efficacious and safe.
DOI:
10.1136/jitc-2022-SITC2022.1368
