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Association details:
| Biomarker: | CA9 overexpression |
|---|---|
| Cancer: | Solid Tumor |
| Drug: | BAY79-4620 (Microtubule inhibitor, CAIX-targeted antibody-drug conjugate) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Therapeutic mechanism and efficacy of the antibody-drug conjugate BAY 79-4620 targeting human carbonic anhydrase 9
Excerpt:
In preclinical human xenograft models in mice representing several tumor indications, BAY 79-4620 showed potent antitumor efficacy and in some models showed partial and complete tumor shrinkage even following a single dose...Efficacy in murine preclinical models correlated semi quantitatively, with CAIX expression levels as determined by immunohistochemistry and ELISA. These preclinical data collectively support the development of BAY 79-4620 for the treatment of cancer patients with CAIX overexpressing tumors.
DOI:
10.1158/1535-7163.MCT-11-0523
